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Background: The outbreak of coronavirus disease 2019 (COVID-19) has caused stress and anxiety for various parts of society all over the world. This concern and stress are not limited to being affected by COVID-19 because this condition has also caused changes in people's lifestyles. Objective(s): The purpose of this study was to design and evaluate the validity and reliability of the COVID-19-related stressors questionnaire and determine the contribution of each of the stressors to the prediction of mental health in the Iranian population. Method(s): This descriptive-analytical and correlational study was performed on 301 volunteers living in Tehran, Iran. Due to the prevalence of COVID-19, questionnaires were distributed by convenience sampling method and online conduction. The instruments used in the present study were the researcher-made questionnaire on Iranians' COVID-19-related stressors (ICRS) and the mental health questionnaire general health questionnaire (GHQ-12). Content validity (qualitative and quantitative), face validity, structural validity (exploratory factor analysis), Cronbach's alpha, and logistic regression were used to analyze the data. Statistical analysis was performed by SPSS version 24 and AMOS24 software. Result(s): In exploratory factor analysis, the final 25 items were obtained in seven factors with an explanation of 66.25% variance. The results of logistic regression analysis showed that worrying about changing economic status, getting COVID-19 and change in lifestyle increased the chance of developing mental health disorder up to 1.29 (OR = 1.29), 1.28 (OR = 1.28), and 1.18 times (OR = 1.18), respectively. The variable of changing family interactions reduces the chance of developing a mental health disorder by 0.85 times (OR = 0.85). Conclusion(s): The COVID-19-related stressors questionnaire is valid and can be used in future research. Identifying the most im-portant stressors associated with the COVID-19 pandemic and determining each contribution to mental health prediction will help health policymakers to make better decisions.Copyright © 2023, Author(s).
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Declaration de liens d'interets: Les auteurs declarent ne pas avoir de liens d'interets.Copyright © 2023
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The emergence of resistant Klebsiella pneumoniae associated with COVID-19 demonstrate a primary challenge for the antimicrobial therapy of infectious diseases and increases the incidence of mortality and morbidity." K. pneumoniae isolated from COVID-19 patient's sputum with ratio (100%). All K. pneumoniae clinical isolates had 100% resistance to ceftriaxone, piperacillin (80%), cefepime (60%), amikacin (40%), and meropenem =levofloxccin (20%). Bacterial isolates gave positive result for mCIM with ratio was 100%, also all isolates produced diversity of beta-lactamases at a rate of 100% by using spectrometry beta-lactamase assay. Costunolide (38.3 %), Rutin (15.33%), Pentadecanoic acid (6.54%), Oliec acid (4.77%), and Caproic acid (3.22%) considered as major compounds in Saussurea costus were identified by GC-Mass spectrometry. The beta-lactamase produced by K. pneumoniae were inhibited by Saussurea costus with a strong statistical significance at P-value: <0.01, while cinamic acid donot effected on beta-lactamase activity. Copyright © RJPT All right reserved.
ABSTRACT
Trace minerals are important elements for the growth and sustainability of the functions of the body’s systems, including the Females Reproductive Tract (FRT). The importance these elements, such as Zinc (Zn), Magnesium (Mg), and Copper (Cu), have structural, protective, and immune roles. Most of them participate in many enzymatic reactions, so they are of crucial importance. During the COVID-19 pandemic. Coronavirus invades the body by binding to the angiotensin-converting enzyme 2 (ACE2) receptors which are expressed in many tissues and organs, such as the FRT. The importance of these minerals was demonstrated through the clear impact of their concentrations within the body in inhibiting or progressing the severity of infection. It also clearly shows their role in supporting the immune system to resist the virulence of the virus through supplements that support the therapeutic courses for COVID-19. In the present study, we evaluate Zn, Mg, and Cu concentrations in three stages of Females Childbearing Age COVID-19 patients (FCA-COVID-19) admitted to a Samarra hospital in comparison to control non-COVID-19 patients. This study was performed in Samarra hospital for the period of September 2021 to August 2022. Blood samples of 105 females divided into groups included: the Comparator group (healthy control group) included 30 apparently healthy subjects (according to age with a range of 20 and 38 years), and the other three groups included 25 patients each group(according to age groups between 20and 38 years) The diagnosis was made real-time reverse transcription polymerase chain reaction (PCR-RT) by the consultant medical staff, where the patients were categorized according to the severity of the disease.The results of this study showed significant differences in Zn, Mg, and Cu concentrations detected in FCA-COVID-19, in which the Zn, Mg, and Cu concentrations were decreased in patient groups compared with control at p= 0.0001. According to current study results and other studies examining the effect of COVID-19 on Zn, Mg, and Cu concentrations, it is suggested that COVID-19 does significantly influence the concentrations of these minerals in Females of Childbearing Age. Also, maintaining the normal levels of these minerals has a great effect in preventing the symptoms of infection from turning from moderate to severe. As well as its role in shortening the period of stay in the hospital. © 2022, Association Res Militaris. All rights reserved.